Table 5. Association from logistic regression models between LEPR variants and waist circumference in the CoLaus study.

SNP	Allele minor/major	OR (95% CI)heterozygote	OR (95% CI)homozygote minor	P(chi2, 2df)	OR (95% CI)additive	P add(1df)	P interaction SNP*sex
rs10128072	G/T	1.11 (0.97–1.28)	1.08 (0.74–1.58)	0.31	1.09 (0.97–1.23)	0.14	0.06
rs7518849	G/A	1.04 (0.87–1.25)	1.99 (0.70–5.66)	0.40	1.08 (0.91–1.29)	0.37	0.51
rs970467	T/C	0.98 (0.84–1.14)	0.53 (0.28–1.03)	0.14	0.93 (0.81–1.07)	0.32	0.56
rs10889553	T/C	1.19 (0.97–1.45)	1.94 (0.36–10.58)	0.18	1.20 (0.99–1.46)	0.06	0.08
rs10889567*	C/T	1.07 (0.93–1.23)	1.02 (0.85–1.22)	0.61	1.02 (0.93–1.11)	0.65	0.30
rs1137100**	G/A	1.01 (0.88–1.16)	0.93 (0.71–1.22)	0.85	0.99 (0.90–1.10)	0.91	0.25
rs3790438	A/T	0.90 (0.78–1.04)	0.90 (0.63–1.30)	0.32	0.92 (0.82–1.03)	0.16	0.16
rs9436746	A/C	1.05 (0.92–1.20	1.19 (0.99–1.42	0.17	1.09 (1.00–1.18)	0.06	0.29
rs2025805	A/G	0.87 (0.76–1.09)	0.92 (0.78–1.09)	0.18	0.95 (0.87–1.03)	0.22	0.22
rs1805096	T/C	1.02 (0.90–1.16)	0.84 (0.70–1.02)	0.12	0.95 (0.87–1.03)	0.21	0.53
rs9436748	T/G	0.85 (0.74–0.98)	0.95 (0.79–1.13)	0.07	0.95 (0.87–1.04)	0.24	0.34
rs7531110	G/T	1.00 (0.88–1.14)	1.03 (0.86–1.24)	0.94	1.02 (0.93–1.11)	0.71	0.06
rs10158279	C/A	1.05 (0.91–1.21)	1.04 (0.87–1.23)	0.82	1.02 (0.94–1.11)	0.63	0.17
rs11585329	A/C	1.06 (0.92–1.21)	0.96 (0.65–1.41)	0.68	1.03 (0.92–1.16)	0.59	0.58
rs3790437***	C/T	0.91 (0.80–1.04)	0.96 (0.70–1.31)	0.37	0.94 (0.84–1.05)	0.25	0.06

Results are odds ratios (95% confidence intervals) from logistic regression models (general model and additive model) including age, sex, height, alcohol consumption, smoking, and the first and second principal components, as covariates. In addition, the result of the interaction with sex is given. Statistically significant results are shown in bold.

*tag of Q223R.

**K109R.

***tag of K656N.