Table 1.
Vaccines trials at an advanced stage in non-small cell lung cancer
| Vaccine | Patient Population | Clinical Trial | |
|---|---|---|---|
|
Allogeneic Tumor Cell Vaccines |
Belagenpumatucel-L (Lucanix®) | IIIA/IIIB/IV | STOP trial – Phase III. Maintenance therapy for patients who have responded to or have stable disease following first-line, platinum-based combination chemotherapy (NCT00676507) |
|
Protein Specific Vaccines |
MAGE-A3 | IB/II or IIIA | MAGRIT trial – Phase III. Adjuvant therapy in patients with resectable MAGE-A3 positive NSCLC (NCT00480025) |
| EGF | IIIB/IV | A Phase II/III trial of recombinant human EGF-rP64K/Montanide ISA 51 vaccine administered to patients after conventional first line chemotherapy (NCT00516685) | |
| MUC-1 | Unresectable stage IIIA/IIB | START TRIAL. Phase III trial of Stimuvax® (L-BLP25 or BLP25 Liposome Vaccine) in patients with stable disease or response following chemoradiation (NCT00409188) |