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. 2011 Oct 18;6(10):e26385. doi: 10.1371/journal.pone.0026385

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Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: SEM image of intimal subendothelial cholesterol crystals in carotid endarterectomy tissue. (scale bar = 50 um) B: Fluorescence microscopy of human carotid endarterectomy specimen (fresh) incubated ex vivo with Alexa Fluor-488 labeled NP (green). Lu: lumen; I: intima; M: media. (scale bar = 500 um) C: ¹⁹F MR spectroscopy of human plaque segment indicating a strong signal and the presence of trapped CE NP in plaque. (ppm: part per million). PFOB standard signal from co-registered control sample is for NP calibration.