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. 2011 Oct 18;6(10):e26035. doi: 10.1371/journal.pone.0026035

Figure 5. Plasma cytokine levels in rats following clopidogrel administration in PG-PS-induced arthritis model (day 21).

Figure 5

Plasma IFN-γ, IL-β and IL-6 levels were elevated in the PG-PS-induced arthritis-treated clopidogrel group. In contrast, plasma levels of IL-10 were significantly lower in the PG-PS-induced arthritis rats compare to the PG-PS-induced arthritis animals alone. Plasma PF4 levels rose in PG-PS-induced arthritis animals (alone and with treatment with clopidogrel; however, no significant differences were observed between these two groups). There were no changes between groups in IL-4 plasma levels. Values represent the mean ± SEM, (n = 4), untreated group (black bar), clopidogrel group (white bar), PG-PS group (light gray bar) and PG-PS treated with clopidogrel group (dark gray bar), * p<0.05 PG-PS-induced arthritis group vs. PG-PS-induced arthritis treated with clopidogrel group.