Table 2.

IC₅₀ values of PAD4 inhibitors^a

Compound #	IC50
1	5.9 ± 0.3 μM
2	22 ± 2.1 μM
3	>10 mM
4	>1mM
5	>1 mM
6	>0.5 mM
7	310 ± 37 μM
8	2.1 ± 0.3 mM
9	310 ± 110 μM
10	>1 mM
11	>1 mM
12	>1 mM
13	500 ± 60 μM
14	230 ± 110 μM
15	19 ± 3.0 μM
16	12 ± 6.4 μM
17	1.9 ± 0.2 μM
18	2.2 ± 0.3 μM

^aGiven that these compounds are time-dependent irreversible inactivators, these IC₅₀ values should be considered apparent measures of affinity.