Table 11.
Compound | R1 | R2 | IC50 (µM) | ||
---|---|---|---|---|---|
hGIIA PLA2 | hGIB PLA2 | pGIB PLA2 | |||
23a | C6H5CH2 | CH3 | 0.011 ± 0.004 | 0.761 | 0.015 |
23b | 2-(C6H5)C6H4CH2 | CH3 | 0.006 ± 0.001 | 0.364 | 0.097 |
23c | 3-(C6H5)C6H4CH2 | CH3 | 0.009 ± 0.001 | 0.57 | 0.007 |
23d | 1-naphthylCH2 | CH3 | 0.009 ± 0.004 | 1.2 | |
23e | n-C8H17 | CH3 | 0.008 ± 0.003 | 0.78 | |
23f | 2-(C6H5CH2)C6H4CH2 | CH2CH3 | 0.004 ± 0.001 | 0.062 | |
23g | 3-ClC6H4CH2 | CH2CH3 | 0.007 ± 0.002 | 0.390 | 0.003 |
24 | C6H5CH2 | CH2CH3 | 0.009 ± 0.001 | 0.228 | 0.048 |