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Group IB and Group IIA PLA2 Inhibition by Oxadiazolones In Vitro and of Mouse Ear Edema
| Compound | IC50 (µM) | Ear Edema | |
|---|---|---|---|
| pGIB PLA2 | hGIIA PLA2 | ||
| 31b | >100 | 4.0 ± 0.9 | |
| 32 | >100 | 0.28 ± 0.02 | |
| 33a | 9 | 47.83 ± 12.34 (1.0 mg/ear) | |
| 33b | 0.1 | ||
| 34a | 7.41 | 0.03 | |
| 34b | >50 | 0.05 | |
| Indomethacin | 43.11 ± 8.79 (0.5 mg/ear) | ||
