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. Author manuscript; available in PMC: 2012 Oct 12.
Published in final edited form as: Chem Rev. 2011 Sep 12;111(10):6130–6185. doi: 10.1021/cr200085w

Table 14.

Group V and Group X PLA2 Inhibition by 1,3,5-Triazepan-2,6-diones

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Compound R1 R2 R3 R4 IC50 (µM)
hGV
PLA2 		hGX
PLA2
35a CH2CH=CHCOOH H H CH2C6H5 12 10
35b CH2COOC(CH3)3 H H CH(CH3)2 12 11
35c H CH2C6H5 H CH2C6H5 11 13
35d CH2COOC(CH3)3 H CH2COOC(CH3)3 CH2C6H5 11 11