Table 15.
Group GIV Cytosolic Phospholipase A2s (cPLA2)
| Subgroup | Initial/common sources |
Residues /Molecular Mass |
Domain | Activation Factor |
Substrate | Activity | Post Translational Modification |
Human chromosome |
Swiss- Prot |
|---|---|---|---|---|---|---|---|---|---|
| GIVA (cPLA2α) |
Human macrophage–like U937 cells/ platelets/RAW 264.7/rat kidney, Ubiquitous |
749/ 85 Kda |
C2 α/ β hydrolase Cap |
Ca2+ PIP2 C1P Phosphor y-lation |
PC, PE, PI High sn- 2AA specificity |
PLA2, PLA1, Lyso-PLA transacylase |
Phosphorylation | 1q25 | P47712 |
| GIVB (cPLA2β) |
Human pancreas/ liver/heart/brain, Ubiquitous |
1012 /100− 114 Kda |
JmjC insert C2 α/ β hydrolase |
Ca2+ | PC, PE No sn-2 specificity |
PLA1, PLA2, Lyso-PLA transacylase |
15q11.2 - q21.3 |
AAD321 35 |
|
| GIVC (cPLA2γ) |
Human heart /skeletal muscle |
541/ 61 Kda |
α/β hydrolase |
PC Low sn-2 AA specificity |
PLA1, PLA2 Lyso-PLA |
Farnesylation | 19q13.3 | AAC328 23 |
|
| GIVD (cPLA2δ) |
Murine placenta | 818/ 91 Kda |
C2 α/ β hydrolase |
Ca2+ | PC, PE | PLA1, PLA2 Lyso-PLA |
15q15.1 |
Q86XP0 .2 |
|
| GIVE (cPLA2ε) |
Murine heart /skeletal muscle/testis/thyroid |
838/ 95 Kda |
C2 α/ β hydrolase |
Ca2+ | PC, PE | PLA1,PLA2 Lyso-PLA |
15q15.1 |
Q3MJ16 .2 |
|
| GIVF (cPLA2ζ) |
Murine thyroid /stomach |
849/ 95 Kda |
C2 α/ β hydrolase |
Ca2+ | PC, PE | PLA1,PLA2 Lyso-PLA |
15q15.1 |
Q68DD2 .2 |