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. Author manuscript; available in PMC: 2012 Oct 12.
Published in final edited form as: Chem Rev. 2011 Sep 12;111(10):6130–6185. doi: 10.1021/cr200085w

Table 5.

Group IB and Group IIA PLA2 Inhibition by Primary Amides of Long Chain Unsaturated Fatty Acids.a


Compound		 XI(50)
pGIB PLA2 hGIIA PLA2
15a 0.0008 0.002
15b 0.0003 0.004
a

XI(50) is the molar fraction of an inhibitor in the lipid layer that is required to reduce the activity of the enzyme in half.