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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: Neuroscience. 2011 Aug 6;194:189–194. doi: 10.1016/j.neuroscience.2011.08.010

Figure 1.

Figure 1

Systemic valproate administration promotes histone hyperacetylation in the brain. Immunoflourescent images show the presence of acetylated histone 3 Lys9 (AcH3 Lys 9) in the substantia nigra (outline) of saline (A) or VPA treated (B) mice (scale bar = 100µm). Representative western blots show increased acetylation of AcH3 Lys 9 in frontal cortex in animals receiving VPA as well as VPA and MPTP, compared to control animals (C). Densitometric analysis showed significant increases in AcH3 Lys 9 (relative to the level of β-actin in each sample) in VPA and VPA/MPTP-treated animals, compared to their respective controls (D). **: p<0.01.