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. Author manuscript; available in PMC: 2012 Oct 27.
Published in final edited form as: Neuroscience. 2011 Aug 6;194:189–194. doi: 10.1016/j.neuroscience.2011.08.010

Figure 3.

Figure 3

Effects of valproate (VPA) treatment on substantia nigra pars compacta (SNc) neuronal survival following 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) treatment. A) Photomicrographs of tyrosine hydroxlase (TH) staining in the SNc (scale bar = 2mm) B) Stereological estimates confirmed a loss of TH immunopositive (TH+) cells in the SNc following MPTP administration. The MPTP-induced decrease in TH+ cells was prevented by VPA administration. C) Stereological estimates confirmed a loss of neurons (Nissl+ cells) in the SNc as a result of the MPTP exposure. Mice receiving VPA and MPTP show a smaller amount of cell loss than animals that received MPTP without VPA. *: p< 0.05, **p< 0.01, ***: p< 0.001.