Table 2. Tethers in yeast and mammals.
This table lists tethers discussed in this review along with known Rab and coat interactions. Coat subunits in parentheses are reported to bind tethers, although it is unclear whether these interactions are direct. Rab1, Rab5, Rab6, Rab7, and Rab11 are mammalian homologs of yeast Ypt1, Vps21, Ypt6, Ypt7, and Ypt31/32
| Yeast
|
Mammals
|
||||||
|---|---|---|---|---|---|---|---|
| Tether | Rab | Coat | Tether | Rab | Coat | ||
| Multi-Subunit Tethers (MTCs) | TRAPPI | Ypt1 | COPII: Sec23 | TRAPPI? | Rab1? | COPII: Sec23 | |
| TRAPPII | Ypt1, Ypt31, Ypt32 | COPI: (Cop1) | TRAPPII | Rab1 | COPI: γ-COP | ||
| COG | Ypt1 | COPI: Sec21 | COG | Rab1, Rab6? | COP: (β-COP) | ||
| Dsl1 | ? | COPI: Cop1, Ret2 | Syntaxin-18 | Rab6? | ? | ||
| HOPS | Ypt7 | AP-3: Apl5 | HOPS | Rab5, Rab7 | ? | ||
|
| |||||||
| Coiled-Coil Tethers | Grh1 | ? | COPII: (Sec23, Sec24) | GRASP65 | Rab1 | ? | |
| Uso1 | Ypt1 | ? | p115 | Rab1 | COPI: β-COP | ||
| ? | ? | ? | R6IP1 | Rab6, Rab11? | Retromer; SNX1 | ||