TABLE 1.
Effects of CsA, FK506, and Rapa on BW, Serum BUN, and Serum Creatinine (Cr)
| Time (days) | Olive oil, 4 ml/kg | CsA, 2.5 mg/kg | CsA, 25 mg/kg | FK506, 0.6 mg/kg | FK506, 6 mg/kg | Rapa, 1 mg/kg | Rapa, 10 mg/kg |
| BW | |||||||
| 1 | 246 ± 5 | 245 ± 4 | 243 ± 4 | 243 ± 4 | 245 ± 3 | 248 ± 17 | 251 ± 3 |
| 7 | 313 ± 8 | 295 ± 8 | 274 ± 6* | 270 ± 3* | 250 ± 6* | 264 ± 6* | 254 ± 4* |
| 14 | 371 ± 6 | 364 ± 12 | 313 ± 10* | 303 ± 6* | 289 ± 7* | 279 ± 8* | 271 ± 5* |
| 28 | 456 ± 7 | 448 ± 19 | 361* | 351 ± 8* | 344 ± 14* | 286 ± 10* | 294 ± 9* |
| BUN | |||||||
| 1 | 12 ± 1 | 14 | 13 | 11 ± 1 | 11 ± 1 | 13 ± 2 | 12 ± 1 |
| 7 | 13 ± 1 | 15 | 18 ± 2 | 17 ± 2 | 21 ± 2* | 16 ± 1 | 17 ± 1 |
| 14 | 16 ± 1 | 15 ± 1 | 32 ± 2* | 20 ± 1 | 28 ± 2* | 22 ± 2* | 19 ± 3 |
| 28 | 18 ± 2 | 18 ± 1 | 44 ± 4* | 26 ± 2 | 47 ± 18* | 25 ± 7 | 20 ± 1 |
| Cr | |||||||
| 1 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| 7 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 |
| 14 | 0.6 | 0.5 | 0.6 | 0.5 | 0.6 | 0.6 | 0.5 |
| 28 | 0.6 | 0.6 | 0.7 | 0.6 | 0.7 ± 0.1 | 0.5 | 0.6 |
*Significantly different from time-matched controls, p < 0.05 (analyzed by ANOVA, followed by Dunnett’s test).