Table 1.
Patient Characteristic | ARV-Experienced Patients failing Treatment (n=45) |
ARV-Naïve Patients (n=45) |
p-value |
---|---|---|---|
Age, median years (Q1–Q3) | 36 (24–51) | 36 (20–78) | 0.65 |
Gender: Female | 28 (65%) | 27 (60%) | |
Black race | 45 (100%) | 45 (100%) | |
CD4 cell count, median cells/mm3 (Q1–Q3) | |||
Current | 174 (9–718) | 123 (8–660) | 0.036 |
Nadir | 57 (3–197) | 0.0004 | |
Vial load, median copies/ml | 6, 653 (225-220,010) | 44,042 (1,702–1,167,759) | 0.0010 |
Current treatment regimen: | Current treatment regimen: | ||
Regimen 1A (d4T, 3TC, EFV) | 23 (51.1%) | Regimen 1A (d4T, 3TC, EFV) | 23 (51.1%) |
Regimen 1B (d4T, 3TC, NVP) | 2 (4.4%) | Regimen 1B (d4T, 3TC, NVP) | 2 (4.4%) |
ZDV, d4T, ddI, NVP | 1 (2.2%) | ZDV, d4T, ddI, NVP | 1 (2.2%) |
ZDV, d4T, 3TC, EFV | 2 (4.4%) | ZDV, d4T, 3TC, EFV | 2 (4.4%) |
ZDV, 3TC, EFV | 13 (29.0%) | ZDV, 3TC, EFV | 13 (29.0%) |
ZDV, 3TC,NVP | 4 (8.9%) | ZDV, 3TC,NVP | 4 (8.9%) |
Of these, 11/27 (40.8%) had previous history of Regimen 1A. 2/27 (7.4%) had a previous history of d4T, 3TC, NVP and EFV; 2/27 (7.4%) had a previous history of d4T and NVP and 1/27 (3.7%) each had previous history of the following: AZT, d4T, 3TC, ddI, EFV; d4T, NVP, EFV; AZT, 3TC, NVP, Lopinivir/Ritonivir; AZT, d4T, EFV; AZT, 3TC, Lopinivir/Ritonivir; AZT, d4T, 3TC, NVP; d4T, 3TC; AZT, d4T, NVP; 3TC, ddI, EFV; AZT, 3TC, EFV; d4T, 3TC, ddI, EFV; and AZT, 3TC,ddI.