Table 4.
Characteristics of included studies in the meta-analysis.
| Study | Methods | Participants | Interventions | Primary Outcomes | Risk of bias* |
|---|---|---|---|---|---|
| Adler 2009 | Open-label, prospective, randomized, controlled, multicenter trial | 1256 patients, mean age, 64.4 years (range 31-87 y) undergoing screening colonoscopy | Wideangle colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (6 endoscopists). Exera II system. | Number of adenomas/number of patients examined |
Unclear |
| Adler 2008 | Open-label, prospective, randomized, controlled trial | 401 patients with a mean age of 59.4 years (SD 13.4) undergoing diagnostic colonoscopy | Wideangle colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (7 endoscopists). Exera II system. | Adenoma detection rate | Unclear |
| East 2009 (abstract) | Open-label, prospective, randomized, controlled trial | 214 high risk adenomas patients with a median age of 65 and 66 years in the NBI and conventional group respectively | Examination with NBI or white light (WLE), with high definition (HDTV) colonoscopes (3 endoscopists). Lucera system. | The number of patients with at least one adenoma detected. | Unclear |
| Inoue 2008 | Open-label, prospective, randomized, controlled trial | 243 patients (NBI mean age, 61.1 SD 13.5; conventional mean age 62.9 SD 11.3) undergoing surveillance or diagnostic colonoscopy | Colonoscopy using either conventional high-resolution imaging or NBI during instrument withdrawal (6 endoscopists). Lucera system. | Mean number of adenomas per patient | Unclear |
| Kaltenbach 2008 | Open-label, prospective, randomized, controlled trial | 276 patients with a mean age of 64 (SD 10) years (range 31 to 89), undergoing screening, surveillance or diagnostic colonoscopy | Wideangle colonoscopy using either conventional high-resolution imaging or NBI (6 endoscopists); back-to-back colonoscopy by the same endoscopist. Exera II system. | Neoplasm miss rate. | Low |
| Paggi 2009 | Open-label, prospective, randomized, controlled trial | 211 patients (from 50 to 69 years) with positive immunologic fecal occult blood tests | Colonoscopy withdrawal in white light versus NBI (6 endoscopists). Exera II system. | The detection rate of adenoma |
Unclear |
| Rex 2007 | Open-label, prospective, randomized, controlled trial | 434 patients aged 50 years or older undergoing screening or surveillance colonoscopy | Colonoscopy withdrawal in white light versus NBI (only one endoscopist; high definition monitors were used). Exera II system. | Number of adenomas | Unclear |
| Sabbagh 2011 | Open-label, prospective, randomized, controlled, multicenter trial | 482 patients with a mean age of 58.3 (SD 12.9) undergoing screening, surveillance or diagnostic colonoscopy | Wideangle colonoscopy using either conventional high-resolution imaging or NBI (3 endoscopists). Exera II system. | Mean number of adenomas | |
*The judgment for each entry involves answering a question, with answers "Yes" indicating low risk of bias, "No" indicating high risk of bias, and "Unclear" indicating either lack of information or uncertainty over the potential for bias