Table 3.
The GALNT2 rs2144300 and rs4846914 genotypes and serum lipid levels between the Mulao and Han populations
| SNP | Genotype | n | TC (mmol/L) |
TG (mmol/L) |
HDL-C (mmol/L) |
LDL-C (mmol/L) |
ApoA1 (g/L) |
ApoB (g/L) |
ApoA1/ ApoB |
|---|---|---|---|---|---|---|---|---|---|
| GALNT2 rs2144300 | |||||||||
| Mulao | CC | 491 | 5.06 ± 1.39 | 1.15(0.84) | 1.74 ± 0.42 | 2.97 ± 0.96 | 1.35 ± 0.39 | 0.99 ± 0.55 | 1.58 ± 0.77 |
| CT | 244 | 5.05 ± 1.16 | 1.05(0.83) | 1.77 ± 0.43 | 2.97 ± 0.92 | 1.35 ± 0.40 | 0.96 ± 0.54 | 1.67 ± 0.81 | |
| TT | 40 | 5.20 ± 1.01 | 0.92(0.92) | 1.73 ± 0.38 | 3.11 ± 0.96 | 1.32 ± 0.40 | 0.97 ± 0.47 | 1.51 ± 0.58 | |
| F | - | 0.542 | 6.874 | 0.505 | 1.037 | 0.115 | 0.024 | 0.947 | |
| P | - | 0.582 | 0.032 | 0.603 | 0.355 | 0.892 | 0.976 | 0.388 | |
| Mulao/male | CC | 208 | 5.12 ± 1.42 | 1.17(1.11) | 1.75 ± 0.42 | 2.86 ± 0.92 | 1.39 ± 0.41 | 1.05 ± 0.64 | 1.56 ± 0.67 |
| CT/TT | 102 | 5.39 ± 0.97 | 1.12(1.20) | 1.73 ± 0.42 | 3.06 ± 0.86 | 1.37 ± 0.35 | 1.10 ± 0.62 | 1.46 ± 0.60 | |
| F | - | 3.107 | -0.118 | 0.000 | 1.859 | 0.003 | 0.721 | 0.931 | |
| P | - | 0.079 | 0.906 | 0.986 | 0.174 | 0.959 | 0.397 | 0.335 | |
| Mulao/female | CC | 283 | 5.02 ± 1.38 | 1.14 (0.65) | 1.72 ± 0.42 | 3.06 ± 0.98 | 1.32 ± 0.37 | 0.95 ± 0.48 | 1.61 ± 0.84 |
| CT/TT | 182 | 4.89 ± 1.20 | 0.99(0.60) | 1.79 ± 0.44 | 2.95 ± 0.96 | 1.33 ± 0.42 | 0.88 ± 0.47 | 1.75 ± 0.84 | |
| F | - | 0.354 | -2.851 | 0.540 | 0.127 | 0.091 | 0.876 | 1.224 | |
| P | - | 0. 552 | 0.004 | 0.463 | 0.722 | 0.763 | 0.350 | 0.269 | |
| Han | CC | 447 | 4.97 ± 1.02 | 1.00 (0.90) | 0.73 ± 0.60 | 2.83 ± 0.86 | 1.32 ± 0.24 | 0.84 ± 0.20 | 1.64 ± 0.46 |
| CT | 232 | 5.05 ± 1.27 | 1.07(0.91) | 1.73 ± 0.44 | 2.90 ± 0.96 | 1.36 ± 0.28 | 0.85 ± 0.22 | 1.68 ± 0.51 | |
| TT | 20 | 4.89 ± 1.51 | 1.10(1.12) | 1.79 ± 0.42 | 3.28 ± 0.67 | 1.41 ± 0.36 | 0.93 ± 0.15 | 1.57 ± 0.52 | |
| F | - | 1.452 | 0.394 | 0.403 | 0.309 | 2.191 | 1.715 | 3.572 | |
| P | - | 0.235 | 0.821 | 0.668 | 0.734 | 0.113 | 0.181 | 0.029 | |
| Han/male | CC | 158 | 5.25 ± 0.96 | 1.32(1.17) | 1.61 ± 0.42 | 3.01 ± 0.81 | 1.31 ± 0.26 | 0.93 ± 0.20 | 1.47 ± 0.41 |
| CT/TT | 108 | 5.21 ± 1.32 | 1.09 (0.93) | 1.71 ± 0.42 | 2.87 ± 0.92 | 1.40 ± 0.30 | 0.89 ± 0.20 | 1.64 ± 0.47 | |
| F | - | 0.120 | -2.085 | 4.795 | 1.156 | 6.432 | 4.478 | 13.073 | |
| P | - | 0.729 | 0.040 | 0.029 | 0.283 | 0.012 | 0.035 | 0.000 | |
| Han/female | CC | 289 | 4.81 ± 1.02 | 0.91(0.78) | 1.79 ± 0.66 | 2.75 ± 0.87 | 1.32 ± 0.24 | 0.80 ± 0.19 | 1.73 ± 0.46 |
| CT/TT | 144 | 4.89 ± 1.25 | 1.06(0.95) | 1.75 ± 0.46 | 2.96 ± 0.97 | 1.33 ± 0.27 | 0.84 ± 0.23 | 1.70 ± 0.54 | |
| F | - | 1.879 | -1.683 | 1.212 | 7.387 | 0.043 | 5.929 | 1.424 | |
| P | - | 0.171 | 0.092 | 0.272 | 0.007 | 0.836 | 0.018 | 0.233 | |
| GALNT2 rs4846914 | |||||||||
| Mulao | GG | 365 | 5.03 ± 1.18 | 1.12(0.83) | 1.75 ± 0.43 | 2.99 ± 0.89 | 1.36 ± 0.38 | 0.99 ± 0.54 | 1.58 ± 0.61 |
| GA | 250 | 5.02 ± 1.11 | 1.07(0.84) | 1.76 ± 0.44 | 2.96 ± 0.86 | 1.32 ± 0.43 | 0.95 ± 0.52 | 1.64 ± 0.77 | |
| AA | 34 | 5.40 ± 0.84 | 1.05(0.79) | 1.72 ± 0.37 | 3.27 ± 0.88 | 1.32 ± 0.38 | 1.05 ± 0.49 | 1.42 ± 0.59 | |
| F | - | 1.810 | 1.253 | 0.089 | 1.911 | 0.787 | 0.343 | 1.430 | |
| P | - | 0.164 | 0.535 | 0.915 | 0.149 | 0.456 | 0.710 | 0.240 | |
| Mulao/male | GG | 159 | 4.97 ± 1.02 | 1.16(1.18) | 1.75 ± 0.46 | 2.86 ± 0.79 | 1.38 ± 0.43 | 1.00 ± 0.59 | 1.58 ± 0.65 |
| GA/AA | 101 | 5.23 ± 0.97 | 1.21(1.04) | 1.74 ± 0.41 | 3.08 ± 0.78 | 1.37 ± 0.39 | 1.05 ± 0.57 | 1.53 ± 0.70 | |
| F | - | 5.626 | -0.553 | 0.012 | 4.170 | 0.007 | 0.305 | 0.108 | |
| P | - | 0.018 | 0.580 | 0.913 | 0.042 | 0.935 | 0.582 | 0.743 | |
| Mulao/female | GG | 206 | 5.08 ± 1.29 | 1.12(0.62) | 1.75 ± 0.40 | 3.09 ± 0.95 | 1.35 ± 0.34 | 0.98 ± 0.50 | 1.57 ± 0.57 |
| GA/AA | 183 | 4.93 ± 1.14 | 1.02(0.71) | 1.77 ± 0.44 | 2.96 ± 0.91 | 1.29 ± 0.44 | 0.91 ± 0.48 | 1.66 ± 0.80 | |
| F | - | 1.434 | -1.597 | 0.117 | 1.419 | 2.219 | 0.839 | 0.530 | |
| P | - | 0. 232 | 0.110 | 0.773 | 0.234 | 0.137 | 0.360 | 0.467 | |
| Han | GG | 418 | 4.97 ± 1.01 | 1.00(0.80) | 1.70 ± 0.40 | 2.85 ± 0.86 | 1.31 ± 0.24 | 0.84 ± 0.19 | 1.63 ± 0.45 |
| GA | 230 | 5.01 ± 1.15 | 1.06(0.95) | 1.80 ± 0.72 | 2.84 ± 0.86 | 1.37 ± 0.26 | 0.84 ± 0.20 | 1.71 ± 0.50 | |
| AA | 32 | 5.16 ± 1.34 | 1.40(1.22) | 1.62 ± 0.40 | 3.41 ± 0.72 | 1.32 ± 0.31 | 0.96 ± 0.17 | 1.43 ± 0.47 | |
| F | - | 0.261 | 2.716 | 3.415 | 4.060 | 2.658 | 3.255 | 3.901 | |
| P | - | 0.770 | 0.257 | 0.033 | 0.018 | 0.071 | 0.039 | 0.021 | |
| Han/male | GG | 151 | 5.23 ± 0.95 | 1.16(1.05) | 1.63 ± 0.38 | 3.00 ± 0.81 | 1.32 ± 0.23 | 0.92 ± 0.20 | 1.50 ± 0.41 |
| GA/AA | 98 | 5.19 ± 1.38 | 1.15(1.23) | 1.67 ± 0.45 | 2.85 ± 0.93 | 1.40 ± 0.33 | 0.89 ± 0.21 | 1.63 ± 0.51 | |
| F | - | 0.136 | -0.149 | 0.253 | 0.532 | 2.429 | 0.762 | 3.096 | |
| P | - | 0.713 | 0.881 | 0.615 | 0.467 | 0.120 | 0.384 | 0.080 | |
| Han/female | GG | 267 | 4.83 ± 1.02 | 0.96(0.73) | 1.74 ± 0.41 | 2.77 ± 0.88 | 1.31 ± 0.24 | 0.80 ± 0.18 | 1.71 ± 0.45 |
| GA/AA | 164 | 4.94 ± 1.03 | 1.04(0.95) | 1.84 ± 0.79 | 2.94 ± 0.82 | 1.34 ± 0.21 | 0.84 ± 0.19 | 1.70 ± 0.50 | |
| F | - | 0.247 | -1.122 | 2.904 | 1.735 | 1.389 | 0.684 | 0.575 | |
| P | - | 0.619 | 0.262 | 0.089 | 0.188 | 0.239 | 0.409 | 0.449 |
SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B;
The values of triglyceride were presented as median (interquartile range). The difference among the genotypes was determined by the Kruskal-Wallis test or the Wilcoxon-Mann-Whitney test.