Fig. 1.

(A) The STH nucleotide and amino acid sequence. The Q7R residue and the changes made to create the mutant constructs are indicated. Underlined are the FseI site used for deletion STHD5 and the PXXP motif. The single tyrosine, Y78, is boxed. (B) Schematic representation of the STH deletion constructs. The Q7R, Y78 and beginning and ending amino acids of each construct are indicated. The two columns on the right indicate the strength of their interaction with tau and Abl: +, strongly positive; +/−, weakly positive; −, negative.