Table 2.

Five- and ten-year hazard ratios for all-cause and breast-cancer-specific mortality based on cancer-specific geriatric assessment (C-SGA) in a longitudinal study of older women with breast cancer (N=660), 1997–2007

		All-Cause Mortality		Breast-Cancer-Specific Mortality
		5-years HR (95% CI)	10-years HR (95% CI)	5-years HR (95% CI)	10-years HR (95% CI)
Model 1:	Deficits in ≥3 C-SGA domains	1.94 (1.42 –2.65)	1.81 (1.45 –2.26)	2.12 (1.30–3.45)	2.19 (1.34–3.57)
Model 2:	Age
	65–69 years	1.0	1.0	1.0	1.0
	70–79 years	1.13 (0.77–1.67)	1.39 (1.07–1.81)	1.37 (0.74–2.53)	1.44 (0.78–2.66)
	80+ years	2.62 (1.71–3.99)	2.91(2.15 –3.93)	2.15 (1.07–4.34)	2.41 (1.19–4.88)
	Stage
	I	1.0	1.0	1.0	1.0
	II	1.24 (0.92–1.67)	1.07 (0.87–1.32)	3.84 (2.15–6.86)	3.8 (2.13–6.79)
	III	1.26 (0.61–2.61)	1.73 (1.11 –2.73)	5.40 (2.09–13.99)	5.87 (2.27–15.22)
	Deficits in ≥3 C-SGA domains	1.95 (1.42–2.67)	1.76 (1.40–2.20)	2.08 (1.27–3.39)	2.13 (1.30–3.49)
Model 3:	Age
	65–69 years	1.0	1.0	1.0	1.0
	70–79 years	1.11 (0.75–1.64)	1.37 (1.05–1.78)	1.32 (0.71–2.44)	1.38 90.75-2.55)
	80+ years	2.37 (1.53–3.69)	2.60 (1.90–3.55)	1.74 (0.84–3.60)	1.94 (0.94–4.01)
	Stage
	I	1.0	1.0	1.0	1.0
	II	1.21 (0.89–1.64)	1.05 (0.85–1.29)	3.76 (2.10–6.74)	3.71 (2.07–6.65)
	III	1.26 (0.12–2.60)	1.74 (1.10–2.74)	5.51 (2.12–14.29)	6.01 (2.31–15.58)
	Education
	Less than 12 years	1.0	1.0	1.0	1.0
	12 years	0.81 (0.54–1.22)	0.78 (0.59–1.04)	0.75 (0.39–1.46)	0.72 (0.37–1.40)
	More than 12 years	0.85 (0.58–1.24)	0.79 (0.61–1.03)	1.01 (0.55–1.84)	0.96 (0.53–1.75)
	Married	0.82 (0.59–1.03)	0.81 (0.65–1.00)	0.57 (0.33–0.97)	0.56 (0.33–0.95)
	Deficits in ≥3 C-SGA domains	1.87 (1.36–2.57)	1.74 (1.35–2.12)	1.95 (1.18–3.20)	1.99 (1.21–3.28)

HR, Hazard Ratio; CI, Confidence Interval; C-SGA, Cancer-Specific Geriatric Assessment

Model 1 includes only C-SGA measure, Model 2 (age and stage adjusted) includes age, stage and C-SGA measure as individual variables, and Model 3 (fully adjusted) includes age, stage, education, martial status, and C-SGA measure as individual variables