MCSNPs which generate heat upon exposure to an oscillating magnetic field, causing the CB[6] rings to slip off the stalks, thus releasing a cargo of either rhodamine B or doxorubicin. No cell death is observed prior to applying a magnetic field (left panel), while 16% of the cells were killed upon the application of an oscillating magnetic field to MCSNPs without doxorubicin loaded in the pores (center panel). When MCSNPs are loaded with doxorubicin and exposed to an oscillating magnetic field, 37% of the cells are killed, with apoptotic bodies indicated by arrows (right panel).