Table 4. Immunological reconstitution in the 7 surviving T-B+NK+ SCID patients after HCT.
Patient | Lymphocyte Absolute Counts (per μL) | CD3 Absolute Count (per μL) | CD4 Absolute Count (per μL) | CD8 Absolute Count (per μL) | CD19 Absolute Count (per μL) | CD16/56 Absolute Count (per μL) | IgG (mg/dL) | IgA (mg/dL) | IgM (mg/dL) | PHA (%) |
---|---|---|---|---|---|---|---|---|---|---|
1a | 704 | 169 | 120 | 99 | 338 | ND | 1130 | 87 | 90 | 9% |
Post boost: 1200 | 1071 | 452 | 621 | 355 | 127 | 1020 | 151 | 122 | 90% | |
1b | 1976 | 439 | 178 | 277 | 1344 | 68 | 1060 | 123 | 66 | 90% |
3 | 2680 | 1876 | 938 | 911 | 429 | 214 | 1220 | 88 | 168 | 100% |
4b | Post BMT: 2300 | <23 | <23 | <23 | 2070 | 207 | n.a. | n.a. | n.a. | 1% |
Post boost: 1000 | 370 | 270 | 70 | 190 | 420 | 1100 | 183 | 91.3 | 100% | |
5a | Post BMT: 750 | 195 | 120 | 75 | 248 | 262 | 1050 | 54.1 | 80.4 | 1% |
Post Boost: 1370 | 1445 | 673 | 693 | 218 | 297 | n.a. | 27.5 | 69 | 100% | |
5b | 1700 | 888 | 273 | 546 | 512 | 256 | 658 | 60 | 211 | 35% |
6 | 2330 | 1701 | 862 | 629 | 468 | 140 | n.a. | 35 | 278 | 64% |
Abbreviations: PHA = proliferation in response to phytohemagglutin (% of control value), n.a. = not available