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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):248–252. doi: 10.1097/QAI.0b013e318228f992

Figure 1. Epitope affinity, TCR avidity, and HLA surface expression play a role in determining CD8+ T-cell immunodominance.

Figure 1

(A) Epitope affinity IC50 nM values were measured for peptides to HLA class I molecules for 69 A-list defined optimal CD8+ T-cell epitopes conserved within the vaccine insert. TCR affinity values were separated by whether or not the responses were recognized by participants who received VRC-HIVADV014-00-VP. (B) TCR avidity log10 EC50 μM values were measured for 52 optimal CD8+ T-cell epitopes recognized by participants who received either VRC-HIVADV014-00-VP or MRK-Gag. Responses were divided by HLA restriction: B27, B57, B35, or other. (C) HLA surface expression as measured by number of antibodies bound per cell for five participants with a B27 HLA type and A24 and/or an A11 HLA type who received VRC-HIVADV014-00-VP.