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Schematic illustrating an involvement of miR-21 in the modulation of BMP4-mediated effects on gene expression in keratinocytes. miR-21 modulates the BMP anti-tumour activity by negative regulation of the expression of BMP-dependent tumour-suppressor genes (Pten, Pdcd4, Timp3 and Tpm1) in keratinocytes. However, the effects of BMP on keratinocyte differentiation mediated through its targets Id1, Id2, Id3 and Msx2 are miR-21 independent.
