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. 2011 Aug 19;20(22):4430–4439. doi: 10.1093/hmg/ddr371

Figure 3.

Figure 3.

Gbe1−/− newborns accumulate abnormal glycogen in multiple tissues. Formalin-fixed, paraffin-embedded sections of whole mouse newborns digested with diastase and PAS stained for glycogen. Control (A) and Gbe1−/− (B) liver sections, note the reduction in cleared areas in the Gbe1−/− liver, reflecting reduction in total glycogen content, while also accumulating PG (×400 magnification). Intercostal muscles control (C) and Gbe1−/− (D) mice (×400 magnification), note the red stained PG. Control (E) and Gbe1−/− (F) heart sections (×40 magnification); boxed area (×400 magnification) from the Gbe1−/− tissue exhibits widespread vacuolization and extensive PG accumulation in comparison to the control (G and H).