Table 3.
Odds Ratio for Fracture, Indirect Treatment Comparison between drugs (Bayesian analysis)
| Non-vertebral fracture | Vertebral fracture | Hip fracture | Wrist fracture | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CrI) | NNT | OR (95% CrI) | NNT | OR (95% CrI) | NNT | OR (95% CrI) | NNT | |
| Denosumab vs Alendronate | 0.99 (0.72, 1.42) | 1,063 | 0.63 (0.38, 0.97) | 26 | 1.30 (0.38, 3.35) | -180 | NR | NR |
| Denosumab vs Etidronate | 1.26 (0.59, 2.69) | -42 | 0.58 (0.26, 1.15) | 23 | 1.43 (0.13, 5.97) | -126 | NR | NR |
| Denosumab vs Ibandronate | 0.89 (0.61, 1.31) | 96 | 0.67 (0.35, 1.19) | 30 | NR | NR | NR | NR |
| Denosumab vs Raloxifene | 0.87 (0.59, 1.30) | 81 | 0.51 (0.29, 0.83) | 20 | 0.71 (0.14, 1.89) | 184 | NR | NR |
| Denosumab vs Risedronate | 1.04 (0.76, 1.54) | -267 | 0.53 (0.32, 0.82) | 21 | 0.94 (0.27, 2.24) | 893 | NR | NR |
| Denosumab vs Teriparatide | 1.29 (0.73, 2.26) | -38 | 1.06 (0.50, 1.99) | -169 | 3.24 (0.17, 16.89) | -25 | NR | NR |
| Denosumab vs Zoledronic Acid | 1.08 (0.73, 1.62) | -134 | 1.16 (0.66, 1.88) | -65 | 1.36 (0.30, 3.48) | -150 | NR | -14 |
| Etidronate vs Alendronate | 0.79 (0.38, 1.61) | 50 | 1.22 (0.54, 2.28) | -48 | 1.91 (0.20, 7.43) | -60 | 3.48 (0.22, 16.27) | NR |
| Ibandronate vs Alendronate | 1.13 (0.82, 1.60) | -83 | 1.00 (0.54, 1.69) | 20,428 | NR | NR | NR | NR |
| Ibandronate vs Etidronate | 1.44 (0.68, 3.06) | -25 | 0.92 (0.37, 1.95) | 121 | NR | NR | NR | -22 |
| Raloxifene vs Alendronate | 1.12 (0.82, 1.55) | -90 | 1.28 (0.78, 1.98) | -38 | 2.47 (0.71, 6.55) | -38 | 2.60 (0.08, 11.84) | -39 |
| Raloxifene vs Etidronate | 1.41 (0.68, 2.96) | -27 | 1.17 (0.53, 2.29) | -62 | 2.76 (0.24, 11.66) | -32 | 1.87 (0.03, 9.82) | NR |
| Raloxifene vs Ibandronate | 1.02 (0.70, 1.49) | -533 | 1.36 (0.71, 2.38) | -29 | NR | NR | NR | -108 |
| Risedronate vs Alendronate | 0.95 (0.71, 1.23) | 212 | 1.21 (0.79, 1.79) | -50 | 1.47 (0.62, 3.31) | -115 | 1.31 (0.10, 5.21) | 3,328 |
| Risedronate vs Etidronate | 1.19 (0.57, 2.49) | -57 | 1.11 (0.52, 2.18) | -95 | 1.65 (0.18, 6.64) | -84 | 0.99 (0.03, 4.68) | NR |
| Risedronate vs Ibandronate | 0.85 (0.60, 1.15) | 70 | 1.29 (0.71, 2.19) | -36 | NR | NR | NR | -25 |
| Risedronate vs Raloxifene | 0.84 (0.57, 1.15) | 65 | 0.98 (0.61, 1.51) | 622 | 0.79 (0.23, 1.96) | 254 | 2.39 (0.05, 11.67) | -10 |
| Strontium vs Alendronate | 1.06 (0.81, 1.44) | -178 | 1.18 (0.78, 1.71) | -58 | 1.89 (0.61, 4.70) | -61 | 4.78 (0.14, 21.71) | NR |
| Strontium vs Denosumab | 1.08 (0.75, 1.53) | -134 | 1.95 (1.20, 2.99) | -12 | 1.98 (0.44, 5.03) | -56 | NR | -13 |
| Strontium vs Etidronate | 1.36 (0.65, 2.86) | -31 | 1.08 (0.51, 2.07) | -127 | 2.09 (0.20, 8.75) | -50 | 3.72 (0.05, 17.44) | NR |
| Strontium vs Ibandronate | 0.95 (0.69, 1.34) | 212 | 1.26 (0.70, 2.15) | -40 | NR | NR | NR | -4 |
| Strontium vs Raloxifene | 0.94 (0.66, 1.34) | 176 | 0.96 (0.60, 1.46) | 243 | 1.03 (0.23, 2.66) | -1,789 | 10.85 (0.08, 41.99) | -6 |
| Strontium vs Risedronate | 1.12 (0.86, 1.57) | -90 | 0.99 (0.67, 1.43) | 1,890 | 1.37 (0.44, 3.10) | -146 | 8.00 (0.15, 38.56) | -3 |
| Strontium vs Teriparatide | 1.38 (0.80, 2.35) | -29 | 1.99 (0.95, 3.66) | -11 | 4.92 (0.26, 24.44) | -15 | 19.69 (0.12, 80.47) | NR |
| Strontium vs Zoledronic Acid | 1.17 (0.83, 1.66) | -64 | 2.17 (1.34, 3.34) | -10 | 1.93 (0.47, 4.98) | -59 | NR | -49 |
| Teriparatide vs Alendronate | 0.77 (0.46, 1.31) | 45 | 0.65 (0.31, 1.26) | 28 | 1.35 (0.07, 5.71) | -154 | 1.69 (0.04, 8.09) | -102 |
| Teriparatide vs Etidronate | 0.98 (0.40, 2.30) | 531 | 0.70 (0.39, 1.45) | 24 | 1.54 (0.03, 9.01) | -100 | 1.33 (0.02, 6.65) | NR |
| Teriparatide vs Ibandronate | 0.69 (0.40, 1.22) | 33 | 0.53 (0.25, 0.98) | 32 | NR | NR | NR | -13 |
| Teriparatide vs Raloxifene | 0.68 (0.39, 1.19) | 32 | 0.55 (0.26, 0.98) | 21 | 0.76 (0.03, 3.27) | 223 | 3.68 (0.02, 15.16) | -16 |
| Teriparatide vs Risedronate | 0.81 (0.49, 1.41) | 55 | 0.55 (0.34, 1.04) | 22 | 1.00 (0.05, 4.18) | NR | 3.20 (0.04, 14.42) | NR |
| Zoledronic Acid vs Alendronate | 0.91 (0.66, 1.30) | 117 | 0.56 (0.34, 0.88) | 22 | 1.24 (0.39, 3.16) | -225 | NR | NR |
| Zoledronic Acid vs Etidronate | 1.16 (0.55, 2.45) | -68 | 0.52 (0.23, 1.04) | 20 | 1.38 (0.12, 5.70) | -142 | NR | NR |
| Zoledronic Acid vs Ibandronate | 0.82 (0.56, 1.19) | 58 | 0.60 (0.31, 1.06) | 25 | NR | NR | NR | NR |
| Zoledronic Acid vs Raloxifene | 0.81 (0.54, 1.19) | 55 | 0.46 (0.26, 0.74) | 18 | 0.68 (0.15, 1.78) | 167 | NR | NR |
| Zoledronic Acid vs Risedronate | 0.96 (0.71, 1.41) | 265 | 0.48 (0.29, 0.74) | 18 | 0.91 (0.28, 2.07) | 595 | NR | NR |
| Zoledronic Acid vs Teriparatide | 1.19 (0.68, 2.08) | -57 | 0.95 (0.45, 1.83) | 216 | 3.11 (0.17, 16.12) | -26 | NR | NR |
NR: Not reported. Results are reported as Odds ratio.