Fig. 1.

Experimental Design Used to Study the Effects of Preventive RIS Treatment in the Offspring of Poly I:C– or Saline (CON)-Treated Dams. Pregnant rats were exposed to poly I:C (4 mg/kg) or saline (CON) treatment on gestation day 15. The resulting offspring from both treatment conditions (poly I:C offspring and CON offspring) were then subjected to chronic treatment with vehicle, 0.045 mg/kg RIS (RIS-low), or 1.2 mg/kg (RIS-high) during the peri-adolescent stage of development between postnatal days (PND) 34 and 47. MRI and behavioral testing of the offspring were conducted in adulthood, from PND 90, in a drug-free state. LI, latent inhibition; DR, discrimination reversal; AIA, amphetamine-induced activity.