RIS Treatment in Peri-adolescence Prevents the Enlargement of Lateral Ventricular Volume in Adult Offspring of Poly I:C–Treated Dams. (A) Representative T2-weighted images at the level of the lateral ventricles (LV) of an adult (4 months) offspring of saline- or poly I:C–injected dams treated with vehicle, 0.045 mg/kg RIS (RIS-low), or 1.2 mg/kg rispridone (RIS-high) in peri-adolescence. (B) LV volume of adult offspring of saline- or poly I:C–injected dams treated with vehicle, RIS-low, or RIS-high. All values are means ± standard error of the mean. *, Significant difference between poly I:C-vehicle and the other 5 conditions (all P values < .002).