Table 2.
Brain Volume of the Offspring of Poly I:C– or Saline-Injected Dams Treated With RIS or Vehicle During Peri-adolescence
| Prenatal Treatment | Preventive Treatment | Brain Volume (mm3; Mean ± SEM) |
| Saline | Vehicle | 1548.1 ± 16.5 |
| RIS-low | 1511.8 ± 17.4 | |
| RIS-high | 1428.4 ± 29.3* | |
| Poly I:C | Vehicle | 1508.1 ± 22.0 |
| RIS-low | 1516.4 ± 16.1 | |
| RIS-high | 1559.3 ± 07.7 |
Note: Brain volume (mm3) of the offspring of saline (CON)- or poly I:C–injected dams treated with vehicle, 0.045 mg/kg RIS (RIS-low), or 1.2 mg/kg RIS (RIS-high) in peri-adolescence and imaged at adulthood. All values are means ± standard error of the mean (SEM).
*Significant difference between offspring of saline-injected dams treated with high RIS and offspring of saline-injected dams treated with vehicle (P < .0001).