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The stimulus duration alternated between 1.0 second (series 1 and 3) and 0.8 seconds (series 2 and 4). Within each series, the temperature was modulated in a pain rating-dependent manner to maintain average pain intensity near a predetermined setpoint (35%). The change in temperature needed to compensate for the change in stimulus duration or ISI served as response variable. Stimulus durations are indicated above each bar, and interstimulus intervals remained constant at 3.0 seconds.
