Table 3.
Proliferative tumor doubling times of prostatic carcinoma.
| Specimen | Tumor | Tumor volume, cc | Block with tumor | Gleason pattern* | BrdU LI % by flow cytometry | T max , days | Growth rate** |
|---|---|---|---|---|---|---|---|
| PBr4 | T1 | 2.823 | T1-F | 3 | 9.1 ± 0.9 | 25.7 ± 4.0 | 25X |
| T1-G | 3 | 4.2 ± 0.5 | 41.5 ± 3.9 | 15X | |||
| T1-H | 3 | 3.7 ± 0.3 | 48.0 ± 4.0 | 13X | |||
| T2 | 0.121 | T2-C | 3 | 3.4 ± 0.3 | 97.9 ± 7.8 | 7X | |
| Muscle | — | — | — | 2.6 ± 0.0 | 636.2 ± 135.1 | — | |
|
| |||||||
| PBr6 | T1 | 0.656 | T1-B | 3 | 3.2 ± 0.3 | 50.7 ± 1.5 | 2X |
| T1-C | 3 | 3.1 ± 0.3 | 51.1 ± 5.7 | 2X | |||
| Muscle | — | — | — | 2.3 ± 0.4 | 98.6 ± 12.7 | — | |
|
| |||||||
| PBr18 | T1 | 0.015 | T1-B | 3 | 5.7 ± 2.2 | 36.6 ± 7.3 | 6X |
| T2 | 0.842 | T2-B | 3 & 4 | 5.2 ± 1.1 | 52.2 ± 7.0 | 4X | |
| T2-D | 4 | 3.8 ± 0.9 | 108.1 ± 14.8 | 2X | |||
| T2-D | 3 & 4 | 3.7 ± 0.7 | 57.4 ± 8.9 | 4X | |||
| T3 | 0.755 | T3-D | 3 | 13.6 ± 1.7 | 17.3 ± 2.6 | 13X | |
| T3-E | 3 | 4.9 ± 0.7 | 73.5 ± 9.1 | 3X | |||
| Muscle | — | — | — | 2.7 ± 0.1 | 221.7 ± 41.8 | — | |
|
| |||||||
| PBr16 | T1 | 7.642 | T1-E | 3 | 2.0 ± 0.1 | 60.0 ± 4.8 | 2X |
| T1-G | 4 | 7.8 ± 0.2 | 19.0 ± 1.7 | 7X | |||
| Muscle | — | — | — | 1.4 ± 0.2 | 137.0 ± 33.0 | — | |
*Gleason pattern: Gleason pattern of the excised tumor section for a given block.
**Growth rate: T max of matched muscle/T max of tumor.