Fig. 2.

HPLC-based activity profiling of Sophora flavescens extract (EtOAc) for GABA_A receptor modulating properties. b The HPLC chromatogram (254 nm) of a semi-preparative separation of 5 mg extract is shown. a Potentiation (in %) of I_GABA through α₁β₂γ_2S GABA_A receptors by 27 fractions of 90 s each fraction is shown above. c Representative currents through α₁β₂γ_2S GABA_A receptors in the presence of GABA (EC_3–10, single bar, control) and currents recorded during co-application of GABA (EC_3–10) and the indicated fraction (double bar). Current recordings for four most active fractions (11, 12, 14, and 15) are shown