Table 2.
Free and hydrolyzed plasma THC, 11-OH-THC, and THCCOOH concentrations (μg/L) from the second dose (day 1, 2000) to 2.5 h after last dose (day 8), during oral THC dosing.
| Specimen collection | No. doses before blood collection | Hours since last dose before blood collection | Free THC, μg/L | Hydrolyzed THC, μg/L | Free 11-OH-THC, μg/L | Hydrolyzed 11-OH-THC, μg/L | Free THCCOOH, μg/L | Hydrolyzed THCCOOH, μg/L | |
|---|---|---|---|---|---|---|---|---|---|
| Day | Time | ||||||||
| 1 | 2000 | 1 | 5 | 6.6 (0.6) | 6.7 (0.5) | 3.9 (0.5) | 9.7 (1.3) | 59.7 (6.3) | 194.3 (33.2) |
| 1 | 2200 | 2 | 2 | 14.4 (7.7) | 14.8 (7.9) | 5.5 (2.0) | 14.5 (4.1) | 63.1 (8.1) | 185.2 (34.3) |
| 2 | 0800 | 3 | 6 | 10.2 (2.6) | 11.4 (2.8) | 5.9 (0.6) | 21.1 (3.3) | 109.0 (11.3) | 330.2 (72.6) |
| 2 | 2000 | 5 | 6 | 8.0 (0.9) | 8.4 (0.8) | 6.4 (0.4) | 17.6 (3.1) | 109.5 (14.3) | 305.3 (46.5) |
| 2 | 2200 | 6 | 2 | 16.4 (4.7) | 17.1 (4.9) | 9.2 (2.2) | 26.0 (5.7) | 131.0 (31.0) | 341.2 (71.5) |
| 3 | 1000 | 8 | 4 | 8.7 (1.0) | 9.8 (1.0) | 8.5 (1.0) | 25.8 (4.5) | 156.2 (19.8) | 410.0 (68.2) |
| 3 | 2000 | 10 | 5 | 9.4 (2.7) | 10.0 (3.0) | 7.0 (1.1) | 18.3 (3.6) | 130.0 (19.5) | 366.6 (64.6) |
| 3 | 2200 | 11 | 2 | 23.7 (6.6) | 24.3 (6.5) | 12.1 (2.8) | 32.8 (9.6) | 161.8 (21.9) | 383.2 (81.4) |
| 4 | 1000 | 13 | 4 | 14.7 (4.0) | 16.2 (4.3) | 11.7 (1.8) | 42.8 (9.5) | 204.1 (38.6) | 493.7 (112.2) |
| 4 | 2000 | 15 | 5 | 11.7 (3.3) | 12.1 (3.5) | 9.0 (1.7) | 24.7 (3.5) | 168.2 (36.3) | 423.8 (98.1) |
| 4 | 2200 | 16 | 2 | 16.1 (2.2) | 17.3 (2.6) | 9.3 (1.5) | 30.8 (6.3) | 155.1 (29.9) | 381.7 (78.4) |
| 5 | 1000 | 18 | 4 | 7.9 (0.8) | 8.8 (0.7) | 8.2 (0.9) | 31.0 (7.7) | 200.0 (27.1) | 507.3 (99.0) |
| 5 | 2030 | 21 | 3.5 | 17.7 (4.0) | 18.8 (3.9) | 13.1 (2.4) | 41.0 (9.3) | 201.7 (41.4) | 495.7 (116.3) |
| 5 | 2230 | 22 | 2 | 42.9 (10.6) | 44.9 (11.4) | 20.3 (3.8) | 71.8 (19.7) | 227.8 (28.4) | 543.5 (102.3) |
| 6 | 1000 | 24 | 4 | 9.7 (2.4) | 10.9 (2.2) | 12.0 (2.9) | 47.4 (15.8) | 243.8 (36.1) | 581.8 (88.1) |
| 6 | 2030 | 27 | 3.5 | 15.5 (3.1) | 16.1 (3.0) | 12.3 (1.2) | 40.7 (9.3) | 211.2 (29.2) | 491.6 (81.5) |
| 6 | 2230 | 28 | 2 | 17.2 (4.2) | 18.8 (4.0) | 13.9 (3.2) | 50.9 (17.5) | 226.7 (46.1) | 511.7 (107.9) |
| 7 | 1000 | 30 | 4 | 8.2 (1.4) | 9.1 (1.3) | 11.1 (2.2) | 38.9 (12.9) | 253.6 (39.9) | 619.6 (110.9) |
| 7 | 2030 | 33 | 3.5 | 29.3 (7.4) | 31.4 (8.0) | 17.1 (3.0) | 53.7 (10.4) | 237.9 (35.3) | 566.3 (83.9) |
| 7 | 2230 | 34 | 2 | 16.6 (2.5) | 17.7 (2.9) | 13.4 (1.5) | 45.0 (6.5) | 227.8 (43.3) | 563.7 (91.6) |
| 8 | 0800 | 36 | 2 | 16.7 (4.6) | 17.5 (4.0) | 18.0 (3.6) | 74.0 (21.6) | 296.9 (56.2) | 619.4 (114.7) |
| 8 | 0930 | 36 | 3.5 | 8.8 (1.3) | 9.7 (1.2) | 12.2 (2.0) | 48.1 (15.8) | 267.0 (45.6) | 621.0 (116.4) |
| 8 | 1030 | 37 | 1 | 18.5 (5.9) | 20.4 (6.2) | 18.7 (5.0) | 59.5 (18.4) | 264.6 (39.9) | 594.2 (117.1) |
| 8 | 1100 | 37 | 1.5 | 15.2 (4.0) | 16.7 (4.3) | 17.9 (4.8) | 66.6 (24.5) | 277.9 (44.1) | 599.9 (115.7) |
| 8 | 1130 | 37 | 2 | 12.5 (2.3) | 13.5 (2.4) | 15.1 (3.7) | 57.6 (21.1) | 271.1 (45.5) | 618.8 (136.4) |
| 8 | 1200 | 37 | 2.5 | 11.3 (1.8) | 12.4 (1.8) | 13.9 (2.6) | 50.2 (17.6) | 264.9 (46.2) | 634.5 (150.2) |
a
Data are mean (SE). Oral THC (20-mg dronabinol) was administered to 6 daily cannabis users throughout the day and night for 7 days.