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. 2011 Apr 14;2011:430549. doi: 10.5402/2011/430549

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Copyright © 2011 Wawaimuli Arozal et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Hematoxylin and eosin staining of the cross-sectional tissue slices of hearts depicting interstitial edema, vacuolization, and degeneration of cardiac fibers (X200). (b) Hematoxylin and eosin staining of the cross-sectional tissue slices of hearts depicting cardiac hypertrophy (X400), (c) Azan-Mallory staining for fibrosis of the cross-sectional tissue slices of hearts. Fibrosis is indicated by the blue area as opposed to the red myocardium (X200). (d) Bar graph showing % fibrosis in each experimental group. Each bar represents mean ± S.E.M. Group control (C) age-matched normal rats; group DNR, DNR-treated rats administered with vehicle; group Carv, DNR-treated rats administered with carvedilol (30 mg/kg/day). *P < .05 versus group Control; ^# P < .05 versus group DNR.