Absolute Contraindications to Heart Transplantation:

Relative Contraindications to Heart Transplantation:

Chronic current systemic infection, including endocarditis Chronic extracardiac infection Active peptic ulcer Continued abuse of alcohol or other drugs Irreversible secondary organ failure unless considering for combined transplant Psychiatric history likely to result in non-compliance and/ or persistent non-compliance with medical therapy Severe peripheral or cerebrovascular disease Malignancy Other life-threatening medical condition, likely to cause death within five years

HIV ( subject to discussion with Medical Director at UK Transplant) Hepatitis B/C Acute pulmonary embolus ( within 3 months) Obesity BMI>30 COPD with FEV1<50% predicted Pulmonary vascular resistance greater than 4 Woods Units Transpulmonary gradient greater than 12mmHg Chronic renal impairment with GFR<50ml/min, unless candidate for combined renal transplant Diabetes with target organ damage Hypercholesterolaemia or other lipid diseases refractory to diet or drug therapy Severe osteoporosis (bone mineral density > 2sd’s less than predicted for age) Amyloidosis Continued smoking Giant cell myocarditis