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. Author manuscript; available in PMC: 2011 Oct 19.
Published in final edited form as: Pediatr Res. 2010 Oct;68(4):344–348. doi: 10.1203/PDR.0b013e3181edb9fa

Figure 3.

Figure 3

Effect of NOS and COX inhibition on pressure (10–120 mm Hg)-induced constriction in C and Beta MCA. A and B: Inhibition of NOS with L-NAME (100 μmol/L) caused an increase in pressure-induced constriction in both C (A: N=4; C: ■; C+L-NAME: □; p<0.01) and Beta (B: N=5; Beta: ●; Beta-L-NAME: ○; p<0.001) MCA. C and D: Inhibition of COX with Indo (10 μmol/L) had no effect on pressure-induced constriction in MCA form C sheep (C: N=5; C: ◆; C+L-NAME: ◇; p=n.s.) but caused significant augmentation of pressure-induced constriction in Beta MCA (D: N=5; Beta: ▲; Beta+L-NAME: △; p<0.01).