. Author manuscript; available in PMC: 2011 Oct 19.

Published in final edited form as: Environ Mol Mutagen. 2009 Jul;50(6):460–472. doi: 10.1002/em.20482

TABLE I.

Observed Cloning Efficiencies at 21 Days Following 3-Day Exposures of TK6 Cells to AZT-ddI (Equimolar) and/or WR1065^a

Treatment group	CE (relative cell survival)^b	P-value^c
Vehicle-control	79 ± 10.9% (NA)^d	–
WR1065 (150 μM)	69.7 ± 5.3% (88%)	0.3
AZT-ddI (100 μM)	27.1 ± 11.0% (34%)	<0.001
AZT-ddI (100 μM) + WR1065 (150 μM)	40.7 ± 13.0% (52%)	0.001

TK6 human lymphoblastoid cells were exposed to vehicle or the given concentrations of AZT-ddI and/or WR1065 for 3 days, and then washed, diluted, and plated after a 7-day expression period under nonselection conditions to measure colony outgrowth as described in the Materials and Methods. Plates were scored 14 days after plating to determine average cloning efficiency (CE).

Adjusted relative cell survival values, in parentheses, represent the ratio of observed CEs in drug-exposed cells versus the average control value.

Mann-Whitney test.

Not applicable.