. Author manuscript; available in PMC: 2011 Oct 19.

Published in final edited form as: Environ Mol Mutagen. 2009 Jul;50(6):460–472. doi: 10.1002/em.20482

TABLE IV.

Impact of WR1065 Treatment on Replication of Influenza A/HKx31 (H3N2) or Influenza B/Lee/40 in MDCK Cell Monolayers^a

Virus	Mean plaque number (% reduction)				P-value^b
Virus	0 μM WR1065	10 μM WR1065	33 μM WR1065	100 μM WR1065	P-value^b
A/HKx31(H3N2)	66.3	59.3 (11%)	57.0 (14%)	47.7 (28%)	<0.05
Influenza B/Lee/40	26.7	24.0 (10%)	20.3 (24%)	18.6 (30%)	<0.05

Infectious virus yields were determined in MDCK cells infected with virus and treated with 0 or up to 100 μM WR1065. Cells in six-well plates were infected with a given species of influenza virus. After 1 hr adsorption, cells were replenished with minimum essential medium containing 0 or up to 100 μM WR1065. At 3 days postinfection, infected cells were frozen and freeze-thawed preparations were titered by plaque assay.

Multiple linear regression.