Fig. 1.

Effects of pharmacological antagonists of Ca²⁺ influx in freshly isolated pulmonary endothelial cells. A: depletion of intracellular Ca²⁺ stores was performed with 20 μM ATP in a nominally Ca²⁺-free HBSS from control rats. Shaded area depicts ATP-induced Ca²⁺ entry by integrating area under the curve (AUC) for statistical analysis. B: inhibitory effects of store- and receptor-operated Ca²⁺ channel antagonists on ATP-induced Ca²⁺ influx. Summary data showing percent inhibition from vehicle control in the presence of 100 μM La³⁺ (n = 4), 100 μM Ni²⁺ (n = 4), and 20 μM SKF96365 (n = 3). Values are means ± SE. *P ≤ 0.05 vs. vehicle and control.