Fig. 2.

A: ATP-induced Ca²⁺ entry was less in cells from chronically hypoxic (CH) rats compared with controls (time control columns). Cholesterol depletion attenuates agonist-induced Ca²⁺ entry in freshly isolated endothelial cells from control rats but not from CH rats. Summary data for ATP-induced Ca²⁺ influx in endothelial cells under cholesterol deplete (mβCD) and cholesterol replete (Chol-mβCD) conditions. Values are means ± SE; n = 4–5/group. *P ≤ 0.05 vs. vehicle and control; **P ≤ 0.05 vs. time control. B: ATP-induced Ca²⁺ release from stores upon stimulation. There were no differences between groups.