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. 2011 Aug 12;301(4):H1331–H1340. doi: 10.1152/ajpheart.00980.2010

Fig. 5.

Fig. 5.

Whole cell ATP-induced inward currents are reduced following CH and are improved in the presence of the cav-1 scaffolding element. ATP-induced (20 μM) currents were difference subtracted from an initial voltage pulse during which extracellular ATP was absent. Current-voltage (I/V) relationships were generated from voltage pulses applied to freshly isolated endothelial cells from control and CH arteries where either the AP-scrambled peptide or AP-cav was introduced via the patch pipette (A). I/V relationships depict the effect of AP-cav on ATP-stimulated endothelial cells from control and CH arteries in the presence or absence of 100 μM La3+ (B). Summary data indicating inward current density at −40 mV for control and CH endothelial cells in the presence of control peptide or cav-1 scaffolding element (C). Values are means ± SE; n = 6 cells/group. *P ≤ 0.05 vs. control AP-scrambled and **P ≤ 0.05 vs. CH AP-scrambled.