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Effect of AOPCP (A) or ZM 241385 (B) on pial arteriolar responses to suffusions of 1, 10, and 100 μM AMP. C: depiction of responses to suffusions of AMP in the absence and presence of adenosine deaminase (ADA; 2 units/ml), ADA + AOPCP (300 μM), and ADA + AOPCP + ZM 241385 (10 μM). Values are means ± SD. *P < 0.05 vs. initial; †P < 0.05 vs. AOPCP; ‡P < 0.05 vs. ADA + AOPCP + ZM 241385; n = 5 per group.
