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Carotid blood flow and vascular resistance. MAP (A), carotid blood flow (CBF; B), and carotid vascular resistance (CVR; C) were determined in anesthetized control (n = 6) and knockout (n = 8) mice using a flow probe fitted to the right carotid artery. Measurements were collected at baseline (0) and in response to an increasing dose of phenylephrine. CVR was also determined in response to nitro-l-arginine methyl ester (l-NAME; D). Values represent means ± SE.
