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. 2011 Aug 19;301(4):H1396–H1404. doi: 10.1152/ajpheart.00121.2011

Fig. 6.

Fig. 6.

Cardiovascular knockout mice fail to develop ACTH-induced hypertension. Systolic blood pressure (SBP) was measured by the tail-cuff method in 3- to 6-mo-old female mice following ACTH treatment (control n = 6; knockout n = 8) or saline (control n = 6; knockout n = 9). Baseline (BS) measurement is the average of 8 consecutive days of basal SBP measurements, followed by 5 consecutive days of ACTH or saline treatment. Values represent means ± SE. *P < 0.05 and #P < 0.05, statistical difference compared with the corresponding ACTH knockout and saline control, respectively.