Table 1.

Morphometric analysis of male and female mice

	4 mo		8 mo
	Control	Knockout	Control	Knockout
Body, g	25.3 ± 1.9	25.4 ± 1.3	36.9 ± 1.6	35.6 ± 1.2
Heart, mg	128.0 ± 7.7	122.0 ± 4.3	170.6 ± 8.0	181.8 ± 9.8
Kidney, mg	319.8 ± 20.1	337.4 ± 22.4	423.7 ± 22.4	428.2 ± 22.7
Heart-to-body weightt ratio	5.0 ± 0.1	4.9 ± 0.1	4.6 ± 0.1	5.1 ± 0.2*
Kidney-to-body weight ratio	12.7 ± 0.4	13.2 ± 0.4	11.5 ± 0.4	12.0 ± 0.4

Values are means ± SE; n = 5 for 4-mo control, n = 8 for 4-mo knockout, and n = 13 for 8 mo.

^*P < 0.04.