Fig. 4.

Microarray analysis reveals that PVAT is more similar to BAT than SAT or VAT. Microarray Computational Environment (MACE) database was queried in ND and HFD conditions for genes with a >2.0 fold change in expression at P < 0.05 level of significance between adipose depots. In ND conditions, PVAT was very similar to BAT, with differential expression of only 228 genes (0.79% of genes); in contrast, expression of 1,229 genes was differentially regulated when comparing PVAT and SAT (4.2% of genes). After high-fat feeding, PVAT became more similar to white adipose, as the number of genes differentially regulated between PVAT and SAT was reduced to 855 (2.9% of genes). White arrows, upregulated; black arrows, downregulated.