Table 2.

Comparative expression of immune cell-enriched genes in VAT, SAT, PVAT, and BAT in normal and high-fat diet conditions

	SAT				VAT				PVAT				BAT
Symbol	ND	HFD	FC	P	ND	HFD	FC	P	ND	HFD	FC	P	ND	HFD	FC	P
Il7r	2,038	1,299	−1.5	0.20	268	2,779	10.4	<0.001	178	350	1.9	0.41	62	164	2.6	0.07
Tlr13	564	531	−1.1	0.87	397	2,404	6.0	<0.001	133	343	2.6	0.20	151	243	1.6	0.14
Il1rn	444	499	1.1	0.56	367	1,923	5.2	<0.001	220	403	1.8	0.16	208	269	1.2	0.12
Cd84	665	574	−1.2	0.54	426	2,079	4.9	<0.001	128	281	2.2	0.28	92	171	1.9	0.05
Mpeg1	1,527	1,292	−1.2	0.58	713	3,311	4.6	0.001	240	555	2.3	0.22	233	520	2.2	0.12
Cd68	2,434	2,160	−1.1	0.67	2,097	6,895	3.3	<0.001	586	1,451	2.5	0.20	500	914	1.8	0.20
Ccl3	303	329	1.1	0.61	207	662	3.2	<0.001	111	194	1.7	0.18	116	182	1.6	0.18
Emr1	1,247	1,177	−1.1	0.84	1,276	3,800	3.0	<0.001	283	604	2.1	0.23	242	475	2.0	0.11
Ccl2	536	556	1.0	0.83	546	1,174	2.1	<0.05	158	225	1.4	0.24	138	185	1.3	0.22
Ccl9	1,457	1,691	1.1	0.56	1,529	3,262	2.1	<0.01	347	780	2.2	0.16	249	467	1.8	0.11
Tnfrsf1b	911	735	−1.2	0.34	682	1,183	1.7	<0.01	226	304	1.3	0.29	184	256	1.4	0.05

Querying the Microarray Computational Environment (MACE) dataset for genes with the greatest fold increase in expression from normal diet (ND) to high-fat diet (HFD) conditions showed that VAT had the greatest increase in expression of inflammatory genes. The same probe sets showed nonsignificant increases in SAT and much smaller signals in PVAT and BAT. Italicized data are for genes that were significantly upregulated.