Table 1.
List of differentially upregulated genes after 3 wk of TAC
| Gene Description | Gene Symbol | Fold Up |
|---|---|---|
| A. Upregulated Genes in β1/β2−/− but not in WT, β1−/−, or β2−/− | ||
| S100 calcium binding protein A9 (calgranulin B) | S100a9 | 4.50 |
| FK506 binding protein 5 | Fkbp5 | 3.17 |
| Metallothionein 2 | Mt2 | 3.06 |
| Tissue inhibitor of metalloproteinase 3 | Timp3 | 2.66 |
| Myb-like, SWIRM, and MPN domains 1 | Mysm1 | 2.56 |
| Stomatin | Epb4 | 2.46 |
| Eukaryotic elongation factor-2 kinase | Eef2k | 2.44 |
| Thioredoxin interacting protein | Txnip | 2.41 |
| Mbt domain containing 1 | Mbtd1 | 2.35 |
| Keratin complex 1, acidic, gene 13 | Krt1-13 | 2.31 |
| Myosin, light polypeptide 2, regulatory, cardiac, slow | Myl2 | 2.28 |
| Flavin containing monooxygenase 2 | Fmo2 | 2.18 |
| Fumarylacetoacetate hydrolase | Fah | 2.18 |
| Zinc finger protein 410 | Zfp410 | 2.13 |
| Homeo box C4 | Hoxc4 | 2.07 |
| Nipped-B homolog (Drosophila) | Nipbl | 2.04 |
| Adipose differentiation related protein | Adfp | 2.01 |
| B. Upregulated Genes in All Other Genotypes (WT, β1−/−, and β2−/−) but not in β1/β2−/− | ||
| Procollagen, type VI, alpha 1 | Col6a1 | 3.08 |
| Transforming growth factor, beta 2 | TGFβ2 | 2.76 |
| 3-hydroxybutyrate dehydrogenase, type 1 | Bdh1 | 2.71 |
| Karyopherin (importin) alpha 2 | Kpna2 | 2.69 |
| CCR4 carbon catabolite repression 4-like | Ccrn4l | 2.54 |
| Phenylalanine hydroxylase | Pah | 2.53 |
| Dynein light chain LC8-type 1 | Dynll1 | 2.42 |
| Lumican | Lum | 2.41 |
| Chemokine (C-X-C motif) ligand 12 | Cxcl12 | 2.39 |
| CDNA sequence BC031181 | BC031181 | 2.35 |
| GTPase, IMAP family member 4 | Gimap4 | 2.31 |
| Tubulin, alpha 4 | Tuba4 | 2.29 |
| Anterior pharynx defective 1a homolog (C. elegans) | Aph1a | 2.28 |
| Dynein light chain LC8-type 1 | Dynll1 | 2.28 |
| Cyclin D2 | Ccnd2 | 2.27 |
| Splicing factor, arginine/serine-rich 3 (SRp20) | Sfrs3 | 2.26 |
| Solute carrier family 33 (acetyl-CoA transporter) | Slc33a1 | 2.20 |
| Apolipoprotein C-II | Apoc2 | 2.17 |
| Jun oncogene | Jun | 2.11 |
| Tubulin, alpha 6 | Tuba6 | 2.06 |
| CAP, adenylate cyclase-associated protein 1 (yeast) | Cap1 | 2.05 |
| Cysteine-rich protein 1 (intestinal) | Crip1 | 2.02 |
Genes are ranked by fold change (only showing those with fold change >2.0; P < 0.01). TAC, transverse aortic constriction.