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. 2011 Aug 12;301(4):H1519–H1530. doi: 10.1152/ajpheart.01080.2010

Fig. 1.

Fig. 1.

microRNA-210 (miR-210) is upregulated in hypoxic cardiomyocytes. A: volcano plot of microRNA expression level and uncorrected P value in the 1.5% O2 for 48 h condition. B: volcano plot of microRNA expression level and uncorrected P value in the 0.5% O2 for 48 h condition. miR-210 is the most strongly induced microRNA in both conditions and, after correction for multiple comparisons, is the only significantly upregulated microRNA (corrected P = 0.04 in the 0.5% O2 condition); n = 3 independent biological samples in each group. C: RT-PCR data confirm that hypoxia upregulates miR-210 in an O2 dose-responsive manner (*P < 0.05 and **P < 0.01). D: miR-210 is induced in neonatal rat cardiomyocytes (NRCM) as soon as 8 h after hypoxia exposure (*P < 0.05 compared with time 0). E: miR-210 levels remain elevated in NRCM up to 120 h after withdrawal of cells from hypoxia (*P < 0.05 compared with time 0). Data are presented as means ± SE; n = 3 in each group.