Fig. 7.

miR-210 reduces mitochondrial biogenesis. A: miR-210 adenovirus overexpression in H9c2 cells reduces signal of nonyl acridine orange (NAO), a marker of mitochondrial mass (**P < 0.01, n = 6). B: miR-210 adenovirus overexpression in NRCM demonstrates similar results (*P < 0.05, n = 6). C: at baseline or after 48 h of 1.5% O₂, anti-miR-210 does not increase mitochondrial mass in H9c2 cells (n = 3). D: results in NRCM were similar (n = 3). E: after 48 h of 0.5% O₂, anti-miR-210 increases mitochondrial mass in H9c2 cells (**P < 0.01, n = 3). F: however, in NRCM treated with 0.5% O₂ for 48 h, no change in mitochondrial mass was seen (n = 3). Data are presented as means ± SE.