Fig. 1.

Representative tracings (A and B) and grouped data (C) illustrating the sympathoexcitatory response to intracerebroventricular (ICV) administration of PGE₂ (0.5 nmol) and the E-class prostanoid (EP) agonist misoprostol (0.5 nmol). ICV injection of these two agents elicited significant increases in paraventricular nucleus (PVN) neuronal activity and simultaneously recorded renal sympathetic nerve activity (RSNA), heart rate [HR; in beats/min (bpm)] and blood pressure (BP), or mean BP (MBP). Integrated (mV) and windowed (spikes/s) is shown. Arrows indicate time of drug injections. Values were expressed as means ± SE; n, number of interventions. *P < 0.05 vs. vehicle (Veh).